Cardiovascular disease is the No. 1 killer of women, and the risk significantly increases after midlife, which is why it’s possible that menopause could contribute to this disease. Menopause is not just a click of a button. It's a multistage transition where women experience many changes that could put them at higher risk for cardiovascular disease. Change in cycle length, which is linked to hormone levels, is a simple metric that could tell doctors who is more at risk.