In a study published in Nature, the team used EVE to assess 36 million protein sequences and 3,219 disease-associated genes across multiple species. Their results suggested that 256,000 previously identified human gene variants currently of unknown significance should, in fact, be reclassified as either benign or disease causing. While the researchers emphasize that EVE is not a diagnostic test, they say it could augment current clinical tools used by geneticists and other physicians to make diagnoses, predict disease progression, and even choose treatment based on the presence of certain disease-causing genetic mutations.